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药筛服务

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    药物筛选是现代药物开发流程中检验和获取具有特定生理活性化合物的一个步骤,系指通过规范化的实验手段从大量化合物或者新化合物中选择对某一特定作用靶点具有较高活性的化合物的过程。药物筛选的过程从本质上讲就是对化合物进行药理活性实验的过程,随着药物开发技术的发展,对新化合物的生理活性实验从早期的验证性实验,逐渐转变为筛选性实验,即所谓的药物筛选。作为筛选,需要对不同化合物的生理活性做横向比较,因此药物筛选的实验方案需具有标准化和定量化的特点。随着组合化学和计算化学的发展,人们开始有能力在短时间内大规模合成和分离多种化合物,因而在现代新药开发流程中药物筛选逐渐成为发现先导化合物的主要途径之一。

    美国DiscoveRX是目前世界上最专业的药筛服务公司之一,默瑞生物是其中国大陆的独家代理商。
    成立于2000年的DiscoveRx是一家私人持股,风险投资支持的公司,总部设在加州弗里蒙特,在英格兰伯明翰设立办事处。公司率先发现beta-糖苷酶片段互补在生物化学和以细胞为基础的实验中对研发的作用,在这方面拥有丰富的知识产权。DiscoveRx致力于开发和新型方法商业化,用以研究Gapers,室壁不随意运动和其他主要的药物靶标类。许多创新产品在全球制药和生物技术新药筛选实验室中广泛应用。DiscoveRx在2008年被授予Frostamulliva两个奖项:主要为了表彰在北美医疗保健市场的创新成果以及欧洲产品战略--GPCR细胞实验组合策略。如需了解更多详细信息,请访问http://www.discoverx.com。

Phenotypic Profiling & Screening Services

Clinically Relevant Data Without Going into the Clinic

Highly Validated Human Primary Cell Culture Models of Disease and Biology

The DiscoverX BioMAP® platform is a service that consists of 60+ human disease models, a database of over 4,500 reference compounds, and expert bioinformatics and data analysis tools to evaluate and interpret test agent data. Overall this platform can be used to inform on the potency, selectivity, safety, mechanism of action (MOA), clinical indication and impact of combination therapy of test agents across therapeutically relevant human disease models.
 


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Unbiased Characterization

Test Agents Across a Broad Range of Human Disease Models with Diversity PLUS™

The Diversity PLUS panel comprised of 12 BioMAP systems is used to inform on the potency, selectivity, safety, mechanism of action and disease indication of a test agent. A profile of biomarker activity of each test agent is generated and compared against the BioMAP reference database and 19 consensus mechanism class profiles of well-characterized drugs.

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Model Complexity of Tumor Microenvironments


BioMAP Oncology Systems

The BioMAP Oncology Systems model the complexity of different tumor microenvironments (TME) by combining primary human stromal or vascular cells with immune cells and human tumor cell lines to mimic interactions and signaling pathways that occur during tumorigenesis.  Use Oncology Panels to gain insight into TME specific mechanism of action, efficacy and safety-related effects of test agents.

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Maximize the Impact of Your Compounds in Combination


Evaluate the Effect of Drug Combinations with BioMAP
Combo ELECT

The BioMAP Combo ELECT service allows statistical evaluation of drug combinations to determine additive or antagonistic differences between drug agents in a nominated disease model of interest. Each agent is analyzed individually, and then statistically compared against a combination array of the two serially diluted agents.  Use Combo ELECT to inform on the optimal dosing, potential synergy or adverse effects of different drug pairings.

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Model the Adaptive Immune Cell Microenvironment


Gain Insight into a Diverse Set of Target Classes Using the
T Cell/Autoimmune Panel

The T Cell Autoimmune panel models the adaptive immune cell microenvironment, as well as the individual T and B cell responses during different types of inflammation. Use the T Cell panel to gain insight into inflammation-related effects, indication guidance and combination feasibility for a diverse set of target classes.

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Model Fibrosis in Various Tissue Environments


Understand Tissue Remodeling with the BioMAP Fibrosis Panel

The BioMAP Fibrosis Panel contains systems modeling the tissue environments of the lung and kidney during the complex inflammatory and pro-fibrotic conditions that occur in fibrotic disease, wound healing and extracellular matrix remodeling.  Use the Fibrosis Panel to gain insight into fibrosis-related effects, compound ranking, indication guidance and combination feasibility for a diverse set of target classes.

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Clinically Relevant Toxicity Insights Before Entering the Clinic


BioMAP Tox Alert™ for Diversity PLUS

The BioMAP Tox Alert service helps you to identify potential mechanisms of toxicity before testing your drug in human patients.

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Create Your Own Customized BioMAP Panel


Flexibility to Choose any Individual or Combination of Available BioMAP Systems

Create a custom panel to focus on project goals anywhere from lead optimization to preclinical safety.
 

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