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DiscoverX 检测试剂
作者:Morey 发布时间:2020-03-24 点击次数:29

 DiscoverX 检测试剂

DiscoverX提供同时具有化学发光和荧光读数的检测试剂,以满足您的药物发现计划的不同需求。DiscoverX的化学发光检测是基于专有的酶片段互补(EFC)技术,而荧光检测是基于激活的荧光染料。这些检测试剂被优化用于多种应用,例如检测基于细胞的蛋白质-蛋白质相互作用、复合蛋白质结合、易位和第二信使分析。DiscoverX的检测试剂是为DiscoverX细胞系设计的,包括cAMP Hunter,InCELL 或PathHunter细胞系、InCELL分析和ProLabel/ProLink (PL/PK)全细胞内的表达或克隆载体。

ProductCat No.Compatible Cell Lines
PathHunter Detection Kit93-0001 SeriesPathHunter β-Arrestin
PathHunter Internalization
PathHunter Pharmacotrafficking
PathHunter Receptor Tyrosine Kinase
PathHunter Cytosolic Tyrosine Kinase
PathHunter Pathway
PathHunter Nuclear Hormone
PathHunter Parentals
PathHunter Flash Detection Kit93-0247 SeriesPathHunter Dimerization
PathHunter Pharmacotrafficking
HitHunter® cAMP Assay for Biologics90-0075LM SeriescAMP Hunter Gs-/Gi-Coupled Cell Line
HitHunter cAMP Assay for Small Molecules90-0075SM Series
KILR® Detection Kit97-0001 SeriesKILR Target Cell Lines/Pools
PathHunter Bioassay Detection Kit93-0933 SeriesPathHunter Bioassay
PathHunter Bioassay ED Detection Kit93-1043 Series
InCELL Detection Kit96-0079 SeriesInCELL Hunter Cell Lines

Product Change Notice
HitHunter cGMP Assay90-0039 Series

PathHunter NPR1 Functional Assay

Detection Kits for Functional Confirmation of EFC Component Expression

ProductCat No.Intended Use
EFC BlocDetect™ Kit92-0004Detect false positive results by identifying compounds that inhibit β-galactosidase complementation or β-galactosidase activity
ProLink Detection Kit92-0006 SeriesDetect ProLink-tagged protein in parental cells expressing ProLink Vectors
PathHunter ProLabel Detection Kit93-0180 SeriesDetect ProLabel-tagged protein in parental cells expressing ProLabel Vectors
PathHunter EA Detection Kit93-0183 SeriesDetect large protein fragment of β-galactosidase (Enzyme Acceptor, EA) in parental cells expressing EA such as ENDO-EA, MEM-EA, NUC-EA, β-arrestin EA, and SH2-EA
PathHunter PL/PK Detection Kit93-0812 Series

For functional confirmation of EFC components with PathHunter Pathway cell lines

Fluorescence Detection Products

ProductCat No.Intended Use
HitHunter Calcium No WashPLUSAssay90-0091 SeriesMonitor GPCR and ion channel activation using Native Calcium Gq-Coupled Cell Lines
Coelenterazine h90-0084
ADP Hunter™ Plus90-0083 SeriesDetect kinase activity by monitoring ATP depletion
ADP Quest™90-0071 SeriesKinase and inhibitor characterization for kinetic or endpoint analysis

 


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